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Inactivation occurs early in the embryonic development, and it is not possible directly to observe it. Male brown widows prefer larger females, as these females are in better condition and are less inclined to eat their mate. The first of these chapters explains sex differences in susceptibility to X chromosome aneuploidy, such as in Turner's syndrome, Klinefelter's syndrome, and the triple X syndrome, as well as in deletions of different parts of the X chromosome and translocations of parts of the X chromosome to autosomes. Mosaicism may also result from the abnormal behaviors of chromosomes during the cell division in the fetus. Sex dosage compensation is intimately related to sex determination in every organism in which occurs. Widow spiders - from the genus geometricus - are sexually dimorphic, meaning the males are significantly smaller than the females. They may orally lubricate the female's genitals or prolong courtship to deter being eaten. The formal term for the silencing of the two X chromosomes in the female is X inactivation, a phenomenon that was initially discovered in mice by Mary Lyon in Gene activity relates to the mechanism of X inactivation by way of a control region inactivation center on the X chromosome that contains a gene X-inactivation—specific transcript, or XIST that produces an RNA that causes inactivation along the length of the chromosome. Vulnerability of males leads to sex-specific disease. In other situations, the mutation may give an advantage to the cell in which it is active and cause the disease to manifest itself in the carrier e. This allows adaptability, since each of the two X chromosomes carries different mutations and polymorphisms that can alter women's susceptibility or resistance to detrimental genes, infectious agents, or other environmental dangers. In some species of spider, the females are considerably larger than the males.
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